pentobarbital will decrease the extent or outcome of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.
pentobarbital will lower the extent or effect of tadalafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Stay clear of mix in pulmonary HTN patients. For clients with ED, keep track of response to tadalafil cautiously on account of probable for diminished effectiveness.
pentobarbital will minimize the level or impact of tramadol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Reduced AUC of tramadol as well as active metabolite (O-desmethyltramadol) when coadministered with robust CYP3A4 and CYP2B6 inducers
pentobarbital will lower the level or effect of piroxicam by influencing hepatic enzyme CYP2C9/ten metabolism. Minimal/Significance Unfamiliar.
pentobarbital will reduce the level or effect of bosentan by impacting hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Not known.
pentobarbital will minimize the extent or result of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Solid or reasonable CYP3A inducers might reduce cobimetinib systemic exposure by >eighty% and lessen its efficacy.
Monitor Closely (one)pentobarbital will decrease the level or impact of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Loss of, or reduced response to tofacitinib might manifest when coadministered with strong CYP3A4 inducers
pentobarbital will lessen the extent or impact of alosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.
pentobarbital will lower the extent or outcome of hydrocortisone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will reduce the level or influence of indinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.
pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Caution/Keep track of. Drugs that maximize delta-aminolevulinic acid synthetase may perhaps reduce hemin result.
pentobarbital here will lower the level or outcome of ixabepilone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will reduce the level or influence of flurbiprofen by influencing hepatic enzyme CYP2C9/10 metabolism. Small/Significance Mysterious.